CDK1

Also found in: Medical.

Acronym	Definition
CDK1	Cyclin Dependent Kinase 1 (protein)

References in periodicals archive ?

They found that after its levels peaked during the day, two proteins, CDK1 and FBXW7, interacted with REV-ERBα to help reduce its levels to a low point by the middle of the night.

The researchers hope to investigate whether pharmacological compounds that block CDK1 may have the potential to treat circadian rhythm disruptions.

How Your Circadian Rhythm Gets Powered Up

Flavopiridol is a potent CDK inhibitor with broad specificity to several kinases including CDK1, CDK2, CDK4, CDK6, CDK8 and CDK9; it arrests the cell cycle at both G1/S and G2/M phases (Senderowicz and Sausville 2000; Schmerwitz et al.

Rohitukine, a chromone alkaloid and a precursor of flavopiridol, is produced by endophytic fungi isolated from Dysoxylum binectariferum Hook.f and Amoora rohituka (Roxb).Wight & Arn

Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): overexpression of NPM, CDK1 and NDRG1 and underexpression of CHES1.

Recurring translocation (10;17) and deletion (14q) in clear cell sarcoma of the kidney

The p21/WAF/Cip protein (p21) binds directly to CDK1, CDK2, and CDK4, and may act as a universal inhibitor of the CDKs' enzyme activity.

The Prognostic Significance of DNA Topoisomerase II-alpha (Ki-S1), p21/Cip-1, and p27/Kip-1 Protein Immunoexpression in Oligodendrogliomas: An Analysis of 91 Cases

The relative expression of CDK1, CDK2, CCNB1, GTSE1, ITPR1, c-MYC, SRGAP3, HIST2H3D, HIST] H3J, TOP2A, CCNA2 and RHOJ was determined.

Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription

The synthesized 2-(2-fluorophenyl)-6,7-methyIenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma eel Is.

Diallyl trisulfide (DATS) inhibits mouse colon tumor in mouse CT-26 cells allograft model in vivo

The protein expression of CDK1 related to the G2/M phase decreased markedly with daidzein treatment, whereas slight expression of cyclins A and B occurred.

Daidzein causes cell cycle arrest at the G1 and G2/M phases in human breast cancer MCF-7 and MDA-MB-453 cells

Casgrande F, Darbon JM (2001) Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclin- dependent kinases CDK2 and CDK1.

Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats

Few data are available concerning the expression status of such cell cycle regulators as cyclins and CDK1s in CML (18).

Flow cytometric evaluation of cell cycle regulators (cyclins and cyclin-dependent kinase inhibitors) expressed on bone marrow cells in patients with chronic myeloid leukemia and multiple myeloma / Kronik Miyelositer Losemi ve Multipl Miyelom Olgularmdaki Kemik Iligi Kaynakh Hucrelerde, Hucre Siklusu Duzenleyicilerinin (Siklinler ve Siklin Bagimli Kinaz Inhibitorleri) Alum Sitometrik Olarak Degerlendirilmesi