They found that after its levels peaked during the day, two proteins, CDK1 and FBXW7, interacted with REV-ERBα to help reduce its levels to a low point by the middle of the night.
The researchers hope to investigate whether pharmacological compounds that block CDK1 may have the potential to treat circadian rhythm disruptions.
Flavopiridol is a potent CDK inhibitor with broad specificity to several kinases including CDK1
, CDK2, CDK4, CDK6, CDK8 and CDK9; it arrests the cell cycle at both G1/S and G2/M phases (Senderowicz and Sausville 2000; Schmerwitz et al.
Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): overexpression of NPM, CDK1
and NDRG1 and underexpression of CHES1.
The p21/WAF/Cip protein (p21) binds directly to CDK1
, CDK2, and CDK4, and may act as a universal inhibitor of the CDKs' enzyme activity.
The relative expression of CDK1
, CDK2, CCNB1, GTSE1, ITPR1, c-MYC, SRGAP3, HIST2H3D, HIST] H3J, TOP2A, CCNA2 and RHOJ was determined.
The synthesized 2-(2-fluorophenyl)-6,7-methyIenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1
and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma eel Is.
The protein expression of CDK1
related to the G2/M phase decreased markedly with daidzein treatment, whereas slight expression of cyclins A and B occurred.
Casgrande F, Darbon JM (2001) Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclin- dependent kinases CDK2 and CDK1
Few data are available concerning the expression status of such cell cycle regulators as cyclins and CDK1s
in CML (18).