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CDK1Cyclin Dependent Kinase 1 (protein)
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We selected TP53, TOP2A, CDK1, CCNB1, CDC20, CCNA2, NDC80, AURKA, BIRC5, CCNB2, KIF11, and MAD2L1, which with worse overall survival situation according to the Kaplan-Meier plotter.
Chen et al., "Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Musgrove, "Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells," BMC Cancer, vol.
The following primary antibodies were used in this study: [alpha]-SMA, [alpha]1(I) procollagen, and fibronectin (Epitomics, San Francisco, CA, USA); TGF-[beta]RI, TGF-[beta]RII, PDGF-[beta]R, EGF-R, and Bcl-2 (Santa Cruz Biotechnology, Santa Cruz, CA, USA); cyclin A, cyclin B1, CDK1, CDK2, Bax, pro-caspase-9, cleaved-caspase-9, pro-caspase-8, cleaved-caspase-8, pro-caspase-7, cleaved-caspase-7, pro-caspase-3, cleaved-caspase-3, full-length PARP-1, cleaved-PARP-1, and [beta]-Actin (Cell Signaling Technology, Danvers, MA, USA).
The following primer pairs for target genes and GAPDH were chosen from the Primer Bank website: Bcl-2: 5'-TAC CTG AAC CGG CAC CTG-3' and 5'- GCC GTA CAG TTC CAC AAA GG-3'; Cdk1: 5'- GGGTCAGCTCGCTACTCAAC-3' and 5'-AAGTTTTTGACGTGGGATGC-3'; p53: 5'-TGT GGA GTA TTT GGA TGA CA-3' and 5'-GAA CAT GAG TTT TTT ATG GC-3'; GAPDH: 5'-TCCTGCACCACCAACTGCTTAG-3' and 5'-GGCATGGACTGTGGTCATGAGT-3'.
Among the enriched genes, CDK1 plays an important role in the cell cycle, while RB1 is a driver gene in several cancer types.
Bladder cancer gene panels used in the Cxbladder Detect urinary test were also examined (CDK1, MDK, IGFBP5, HOXA13 and CXCR2).
They found that after its levels peaked during the day, two proteins, CDK1 and FBXW7, interacted with REV-ERB?
miRNA miR function Regulation miR-15a Tumor suppressor Down miR-125b Targets p53, stress response miR-199b Oncogene activation miR-218 Tumor suppressor miR-31 Apoptosis, tumor suppressor Up miR-21 Fatty acid synthesis, apoptosis Up miR-452 Targets CDK1 Down miRNA Tissue/cell type miR-15a Primary bronchial epithelial cells miR-125b miR-199b miR-218 miR-31 Normal and cancer lung cells miR-21 Human squamous carcinoma cells miR-452 Human alveolar macrophages miRNA Source miR-15a Schembri et al.
(87) In addition, interestingly, DNMT3A-R882H could form a complex with cyclin-dependent kinase 1 (CDK1) with higher capacity than wild type DNMT3A, leading to increased CDK1 protein and enhanced cell cycle progression, suggesting a gain-of-function as well.
With the treatment of ZER and ZER-NLC, MDA-MB-231 cell cycle arrest at G2/M phase is proposed to occur through increased expression of cyclin B1, Cdk1, Cdc25C, and Cdc25B proteins [23].
The expression of miR-16 in human PCa is decreased compared with normal prostate tissues, and evaluation of cellular models has shown that miR-16 inhibits prostate tumor growth through expression regulation of such genes as cyclin-dependent kinase 1 (CDK1) and CDK2, which are involved in controlling the cell cycle and proliferation [61].