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Altering Cdk5 activity made the brains of the flies appear genetically to be about 15 days old and their bodies to be about 20 days old.
Sasaki et al., "Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease," Genes to Cells, vol.
In terms of the treatment of PD, pharmacological inhibitions for inflammasome activation-related molecules, such as caspase-1, microRNA-7, CTSB, c-Abl, and Cdk5, may open up novel therapeutic avenues.
Cyclin-dependent kinase 5 (CDK5) is involved in activation of microglia and astrocytes and may serve as a potential therapeutic target for PPAR[gamma] agonist therapy.
Previous studies on pediatric cancer have shown high expression of the two proteins Cyclin-dependent kinase 5 (Cdk5) and Transforming Growth Factor beta (TGF-8).
In brief, rat models treated with nicotine and mimicking a coexisting intermittent hypoxia state showed that nicotine-induced hypoxia reduces the expression of cyclin-dependent kinase 5 (Cdk5), an indispensable gene in the central nervous system, and plays a critical role in neurodevelopment  and delayed neuronal migration .
Li et al., "Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety, "Nature Communications, vol.
PRKCZ (potein kinase C, zeta), EDNRB (endothelin receptor type B), CDK5 (cell division protein kinase 5), and CACNA1A (cav2.1 P/Q voltage-dependent calcium channel) were related to nervous system diseases.
Washington, June 29 ( ANI ): A new research has revealed that inhibiting Cdk5 enzyme could help minimize brain damage if administered shortly after a stroke.
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory.
Iqbal, "Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain," The FEBS Letters, vol.
GSK3, PKC, and PKA showed maximum involvement in phosphorylation while other kinases like PKG, p38MAPK, cdk5, CKII, cdc2, ATM, and CKI also showed potential for phosphorylation of many Ser and Thr residues.
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- CDK-interacting protein 1
- CDK-interaction protein 1
- CDK2-associated dual specificity phosphatase
- CDK2-associated dual-specificity phosphatase
- CDK4 gene
- CDK4 gene
- CDK4 inhibitor p16-INK4, INK4a
- CDK4B inhibitor
- CDK5-Binding Protein
- CDK6 inhibitor p18
- CDK8 protein kinase
- CDK8-like cyclin-dependent kinase
- CDK9-associated C-type protein