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CDK8Cyclin-Dependent Kinase 8
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The most advanced programs at Selvita are SEL24, a pre-clinical PIM/FLT3 kinase inhibitor, with multiple indications in hematopoietic tumors and SEL120, first-in-class small molecule inhibitor of cyclin dependent kinase CDK8.
3] Human genes: HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog; CDKN2C, cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog; CDK8, cyclin-dependent kinase 8; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; BRAF, v-raf murine sarcoma viral oncogene homolog B1.
When further investigating macroH2A function in melanoma, the researchers found that it regulates CDK8, a known oncogene for colorectal cancer.