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Res] tambien se observaron bajos niveles de ARN polimerasa II en el 5' LTR proviral junto con altos niveles de HDACl, ademas de bajos niveles nucleares de CycT1 y de CDK9 (33).
According to Probiodrug AG, CDK9, which has been implicated in the transcriptional regulation of genes involved in proliferation and inflammation, is a promising target for the treatment of both cancer and inflammatory diseases.
Seliciclib is an orally available molecule that selectively inhibits multiple enzyme targets, CDK2/E, CDK2/A, CDK7 and CDK9, that are central to the process of cell division and cell cycle control.
M2 EQUITYBITES-January 3, 2014-Probiodrug divests its CDK9 Inhibitor Programme to AstraZeneca for undisclosed sum
M2 PHARMA-January 3, 2014-Probiodrug divests its CDK9 Inhibitor Programme to AstraZeneca for undisclosed sum
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- CDK2-associated dual specificity phosphatase
- CDK2-associated dual-specificity phosphatase
- CDK4 gene
- CDK4 gene
- CDK4 inhibitor p16-INK4, INK4a
- CDK4B inhibitor
- CDK5-Binding Protein
- CDK6 inhibitor p18
- CDK8 protein kinase
- CDK8-like cyclin-dependent kinase
- CDK9-associated C-type protein