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CDKN2Cyclic AMP (Adenosine Monophosphate)-Dependent Kinase Number 2
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To our knowledge, the association of rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs1387153 (MTNR1B), rs7578597 (THADA) [25], rs243021 (BCL11A) [26], and rs1333051 (CDKN2) [27] was for the first time replicated in an Asian sample.
p16 (INK4a) es una proteina codificada por el gen supresor CDKN2 (MST1, INK4[alpha]) ubicado en el cromosoma 9p21, la cual resulta ser inhibidora de las quinasas dependientes de ciclinas, cdk4 y cdk6, que intervienen en la regulacion de la fase G1 del ciclo celular.
There has also been much attention paid to another tumor suppressor gene, CDKN2, that codes for the cell cycle regulatory protein cyclindependent kinase-4 inhibitor (p16).
Indeed, several studies have indicated that in prostate cancer, in which expression of hCG[beta]-3, -5, or -8 does not occur on malignant transformation (6), DNA hypermethylation is a frequent mechanism leading to inactivation of key regulatory genes such as E-cadherin, [pi]-class glutathione S-transferase, the tumor suppressors CDKN2 and PTEN, and insulin-like growth factor-II [for a review, see Ref.
Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus.
CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families.