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The azole-resistant strain (12-99, hereafter RCa) overexpresses the transporter genes CDR1, CDR2 and MDR1, whereas the sensitive strain (2-76, hereafter SCa) has a basal expression of these genes (White et al., 2002).
Several molecular mechanisms that contribute to drug resistance have been identified, including increased mRNA levels for two types of efflux pump genes: the ATP binding cassette transporter CDRs (CDR1 and CDR2) and the major facilitator MDR1 (Mah, 2012; White et al., 20[O.sub.2]).
If the coefficients are zero, the existence of an asymmetry depends upon the CDR2 coefficients.
No CDR2 terms enter the model for these nations, suggesting that dynamics of growth are reinforced for recessionary periods.
The growth models for Germany do not show this bifurcation into models involving only CDR1 or only CDR2. In fact, for Germany the model with the split CDR definition includes one lag of CDR1 and one lag of CDR2 in place of the one lag of the original CDR.
We could detect only one amino acid substitution in the heavy chain CDR2 region T(4F6) [right arrow] I(3D2).
dubliniensis possess two different types of efflux pumps: adenosine triphosphate--binding cassette (ABC) transporters encoded by the CDR genes (CDR1 and CDR2) and major facilitators encoded by the MDR genes (2,12,26 28).
albicans MDR1, CDR1, and CDR2 genes during both planktonic and biofilm modes of growth.
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