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The highly conserved nature of most HSV, ChHV, and simian virus proteins argues for the homologous proteins of each virus having similar functions.
Despite the lack of a discernable simian homolog of the HSV RL1 gene (or an overlapping ORF P gene on the opposite strand), the RL1 region between the RL2 start codon and the 'a' repeat of the simian virus genomes (1844-2146 bp) is about the same size as in HSV and ChHV (2048-2154 bp).
As in HSV2 and ChHV, the three simian viruses all have three miRNAs, a potential TATA sequence, and both ICP4 and SP1 binding site motifs that are likely control elements for transcription of L/ST RNAs [138].