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(13) While this study highlighted the acute need for a safety regimen to safeguard workers' health, it also showed for the first time that parasites grown in culture and capable of infecting a mosquito could also retain infectiousness to humans, inadvertently paving the way for CHMI.
The first CHMI was performed in 1985 as a proof-of-concept trial to assess whether 6 volunteers would develop malaria after being bitten by 5 mosquitoes infected with NF54.
Soon after the debut of CHMI, a second mosquito-biting-humans method was developed, in which volunteers were exposed to hundreds or even thousands of bites from mosquitoes infected with attenuated parasites.
Every aspect of producing infected mosquitoes, from obtaining enough blood and serum to rearing enough mosquitoes to having the tools and infrastructure to safely handle so many infectious mosquitoes, was reexamined and retooled to meet the needs of CHMI. General rearing rooms were outfitted with specialized equipment to improve insect production and increase efficiency, while smaller equipment such as aspirators to transfer mosquitoes, water jacketed membrane feeders, and mosquito containment devices underwent multiple rounds of innovation to comply with increased demand and increased safety precautions.
CHMI has the distinct advantage of using a pathogen that is susceptible to available drugs and can be completely cured by a simple dosing regimen.
The Washington state CHMIS is probably the most advanced of the seven, with a fully mandated CHMIS and plans for a central data repository roll out in July 1995, according to Sharp.
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- Chmielnicki, Bohdan
- Chmod (Unix)
- Chmshkian, Georg
- Chmshkian, Georg Arutiunovich