CHRCCCherry Hill Regional Chamber of Commerce (Cherry Hill, NJ)
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75,82) The typical growth pattern of sheets of cells separated by incomplete vascular septae in ChRCCs can be a useful finding in distinguishing these tumors from CCRCCs, which classically have thin blood vessels that completely envelope nests of tumor cells.
The staining profile with carbonic anhydrase IX is negative in most ChRCCs and when positive, it is usually patchy and seen in association with necrosis.
Similarly, ChRCCs are well circumscribed, solid, and homogeneous with a tan to brown color and a central scar that is less commonly (about 15% of cases) seen than it is in RO.