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Out of the 50 cases studied, 43 cases were CCRCC, 5 cases were PRCC and 2 cases were ChRCC. For CCRCC, most of the tumours (44.2%) were VEGF Grade-1 with 41.9% Grade-2 tumours and 14% of Grade-0 tumours.
For ChRCC all the cases were with Ki-67 labelling index<15% (100.0%).
Interestingly, chRCC is also a rare malignancy accounting for roughly 5-10% of cases of diagnosed RCC, which translates to projected 3200-6400 cases in the United States in 2016 [47, 48].
Histopathological examination showed well-circumscribed eosinophilic variant of ChRCC. The tumour consisted of medium to large, round, and polygonal neoplastic cells that exhibited mild degree of nuclear pleomorphism and arranged predominantly in variably sized nests, cords, and poorly formed acini and had hyperchromatic nuclei, indistinct nucleoli, irregular "raisinoid" or round nuclear cell membranes, abundant amount of dense eosinophilic cytoplasm, and poorly defined cell membranes (Figures 2(a)-2(c)).
We describe the cytologic features of ChRCC diagnosed by FNA in two cases with histochemical, immunohistochemical and cytogenetic findings.
The purpose of the current study was to explore MPM as a potential alternative and rapid diagnostic tool for differentiating oncocytoma from chRCC. Because this was a proof-of-concept study, typical cases (readily diagnosed with H&E) of oncocytoma and chRCC were included, with the aim of characterizing unique MPM signatures of each tumor type that could aid in their differential diagnosis.
Succinate dehydrogenase-deficient RCC is typically negative for CD117 and CK7 expression, which along with the morphology helps distinguish it from ChRCC. Immunohistochemistry with SDHA and SDHB is useful (and, perhaps, even required) for the diagnosis of SDH-deficient RCC; loss of cytoplasmic SDHA staining indicates a mutation in SDHA, whereas loss of cytoplasmic SDHB staining signifies a mutation in either SDHB, SHDC, or SDHD (Figure 3D).
Renal Epithelial Tumor With Clear Cell/Granular Cell Features.--Three main entities are included in this group: low-grade CRCC, ChRCC, and oncocytoma.
In general, patients with stage pT1 and pT2 chRCC are almost always cured by surgery, and presentation with pT3 or pT4 disease is rare.
Of these 2 types of ChRCC, usually the classic type arises as a diagnostic possibility when dealing with a renal tumor with cytoplasmic clarity.
The overlapping features of the RO and ChRCC neoplasms start at the macroscopic level.
(1-4) Histologically, renal oncocytoma may mimic eosinophilic variants of chromophobe renal cell carcinoma (ChRCC), clear cell carcinoma, and type 2 papillary renal cell carcinoma.
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