(3) ADNFLE, the genetic variation of NFLE, is underpinned by mutation of the nicotinic acetylcholine receptor a4 (CHRNA4
) andb2 (CHRNB2) subunit on the 20q13 and 15q24 chromosome.
Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4
), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients.
The actual mutation is on the CHRNA4
gene that changes the genetic make-up for the Alpha 4 subunit on the nicotinic acetylcholine receptor.
A polymorphism in the [alpha]4 nicotinic receptor gene (Chrna4
) modulates enhancement of nicotinic receptor function by ethanol.