It is also approved to treat adult patients with cIAI
caused by susceptible Gram-negative microorganisms such as Bacteroides caccae, Bacteroides fragilis, Bacteroides ovatus, Bacteroides stercoris, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Fusobacterium nucleatum, Klebsiella aerogenes, Klebsiella oxytoca, Klebsiella pneumoniae, Parabacteroides distasonis and Pseudomonas aeruginosa.
Approval was partly based on data showing the efficacy and safety of imipenem-cilastatin, which has been previously approved by the FDA, in treating cUTI and cIAI
, as well as data from in vitro studies and animal models of infection evaluating the efficacy of relebactam.
The determination of efficacy of Recarbrio was supported in part by the findings of the efficacy and safety of imipenem-cilastatin for the treatment of cUTI and cIAI
. The safety of Recarbrio, administered via injection, was studied in two trials, one each for cUTI and cIAI
Tigecycline is not an appropriate empiric option as monotherapy for the treatment of patients with cIAI
at risk of infection with P.
Mortality was also higher in patients treated with tigecycline for complicated skin and skin structure infections (cSSSI) and complicated intra-abdominal infections (cIAI
) (both approved indications), and diabetic foot infections (an unapproved indication), when compared with other antibiotics: Among those with cSSSI, 1.4% of those treated with tigecycline died, vs.
5.1 Tigecycline has been studied in four phase III double-blind, randomised, multicentre comparator clinical studies in adult hospitalised patients with cIAI
My research mentor for this project was the Centre of Integration for African Immigrants (CIAI
Some actually resemble policies implemented with considerable life-enablement in contemporary Brazil (Ciai
Memorandum, Army Material Command, AMCTC Item 5390, SUBJECT: ABCA-ARMY-STD-158, Mask, Protective, Tank, M14A2; Carrier, Field Protective, Mask, Ml3A1 & Canister, NBCW Protective Mask, M14 (CIAI
), 8 June 1967.
The strategies governing military careers were consistent from one generation to the next: 8 Bichi, along with 7 men from the house of Ciai
and 6 Accarigi, appear as Knights of Malta.
In June at the SIS Congress in Coronado, California, the Company presented positive data from three studies further evaluating XERAVA in complicated intra-abdominal infections (cIAI
), as well as data from a retrospective study of hospital-based outcomes in cIAI
, underscoring XERAVA's role as an empiric treatment option for patients with this type of infection.