CIHH Treatment Increased Both the Hematopoietic Progenitor Cells (HPCs) and Mesenchymal Progenitor Cells (MPCs) in AA Rats.
While in CIHH + AA rats, numbers of MPCs were 16.82 [+ or -] 0.94, 29.55 [+ or -] 1.07, and 42.36 [+ or -] 1.57 at 14d, 19d, and 25d CFU-Fs per 106 cells (n = 30), respectively, which significantly increased compared with AA rats (p <0.01).
CIHH Treatment Increased the Expression of VLA-4, VCAM-1, and ICAM-1 and Decreased the Expression of CD162 and CD164 in BMMSCs of AA Rats.
CIHH Treatment Decreased the Expression of HIF-1[alpha] and NF-[kappa]B in BMMSCs.
In the present study, CIHH treatment reduced the incidence rate of AA, improved the abnormality of hematological parameters in peripheral blood of AA rats, and restored the destroyed bone marrow tissue in AA rats.
The result in our study showed that CIHH could effectively antagonize the decreasing of bone marrow CFU-F, recover the mature fibroblast-like stromal cell layer that formed in bone marrow, and support the hematopoiesis of bone marrow in AA rats.
At high altitude, there was a significantly lower pC[O.sub.2] at rest in CIHH subjects compared to controls, and BE tended to be lower (Table 4).
Here, endothelin-1 was increased at high altitude compared to low altitude in CIHH as well as in control subjects (Figure 3, p < 0.01).
Since sPAP was lower and Sp[O.sub.2] higher in CIHH than in controls, we further investigated a possible correlation between sPAP and Sp[O.sub.2] during exercise at high altitude and found a negative correlation that was not statistically significant (Figure 4).
To our knowledge, this is the first study investigating the influence of daily CIHH on pulmonary arterial pressure.
While studies of chronic exposure have consistently shown chronic increases in PAP in high-altitude dwellers [2, 11, 20], results obtained for CIHH are less clear [14-16, 21, 22].
Of note, in the present study sPAP under exertion at low and high altitude was even lower in CIHH subjects compared to controls.