CIMDLCocaine-Induced Midline Destructive Lesions
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
(6,7) In 1997, Helie and Foumier reported that 17 cases of CIMDL had been described in the literature, four of which had involved the hard palate.
For the purpose of this article, a patient is considered to have a CIMDL if he or she has at least two of these three conditions: (1) a nasal septal perforation, (2) lateral nasal wall destruction of the inferior or middle turbinate in the maxillary or ethmoid sinus, or (3) hard palate involvement, either clinically or radiographically.
Several factors are involved in the pathophysiology of a CIMDL. They include local ischemia secondary to vasoconstriction, chemical irritation from adulterants put in "cut" cocaine, and infection secondary to trauma, decreased humoral and cell-mediated immunity, and impaired mucociliary transport: