CIN 2Cervical Intraepithelial Neoplasia Grade 2
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On histopathology, 144 (65.45%) were benign showing chronic cervicitis, whereas 52 (23.64%) and 24 (10.9%) cases were diagnosed as CIN 1 (LGL) and HGL (CIN 2, CIN 3) respectively (Table 2).
This study comprised 43 women in the control group (mean age 33.8 [+ or -] 9.3), 53 in the CIN 1 group (mean age 32.2 [+ or -] 9.1), 60 in the CIN 2 group (mean age 30.9 [+ or -] 7.5), and 78 in the CIN 3 group (mean age 36.0 [+ or -] 8.4), with ages ranging from 18 to 59 years old.
Group 3: Cervicitis and CIN 2: Of the 50 women in this group, 8 still had a bacterial and/or fungal cervicitis that required treatment.
As for group II, the diagnosis of severe grade of dysplasia of squamous epithelium (CIN 3) was made in 17 (50%) patients , a moderate dysplasia of squamous epithelium (CIN 2) and mild dysplasia of squamous epithelium (CIN l) was found in 10 (29.41%) and 7 (20.59%) cases, respectively.
Among 2,796 women (mean age, 39.5 years) who underwent random biopsy, the findings were normal, CIN 1, CIN 2, and CIN 3 in 90.0%, 5.7%, 1.3%, and 1.4%, respectively.
Persistent HPV infections and the development of CIN 2,3
The statistical analysis was done for normal samples, CIN 1 samples, and CIN 2 and CIN 3 that were analyzed as one group (severe neoplasia).
While the same 24-month conservative pathway should be followed for adolescent patients with biopsy-proven CIN 1 or CIN 2 to allow for regression, the management options for adolescents and young women with a histologic diagnosis of CIN 2,3 include treatment using either excision or ablation of the T-zone depending on the adequacy of the colposcopic exam, or colposcopic and cytologic observation at 6-month intervals for 24 months, "as long as colposcopy results are normal and cytology is negative," he said.
The undercall (less than CIN 2 on colposcopy and more than CIN 1 on histology) with colposcopy was 5.8%.
Some studies show that CIN 2 is an intermediate entity that lies between CIN 1 and CIN 3 and has some premalignant potential although not as great as that of CIN 3.