CIN 3

AcronymDefinition
CIN 3cervical intraepithelial neoplasia grade III
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Distribution of Study Participants based on Biopsy Findings (n = 220) Biopsy Findings Frequency Percent Benign 144 65.5 CIN 1 52 23.64 CIN 2 8 3.6 CIN 3 16 7.3 Total 220 100.0 Table 3.
This study comprised 43 women in the control group (mean age 33.8 [+ or -] 9.3), 53 in the CIN 1 group (mean age 32.2 [+ or -] 9.1), 60 in the CIN 2 group (mean age 30.9 [+ or -] 7.5), and 78 in the CIN 3 group (mean age 36.0 [+ or -] 8.4), with ages ranging from 18 to 59 years old.
As for group II, the diagnosis of severe grade of dysplasia of squamous epithelium (CIN 3) was made in 17 (50%) patients , a moderate dysplasia of squamous epithelium (CIN 2) and mild dysplasia of squamous epithelium (CIN l) was found in 10 (29.41%) and 7 (20.59%) cases, respectively.
Among 2,796 women (mean age, 39.5 years) who underwent random biopsy, the findings were normal, CIN 1, CIN 2, and CIN 3 in 90.0%, 5.7%, 1.3%, and 1.4%, respectively.
"Cotesting" refers to the combination of cytology and HPV testing, which increases the ability to detect CIN 3 and allows for a decrease in the interval of screening because of the low risk associated with a negative screen.
The statistical analysis was done for normal samples, CIN 1 samples, and CIN 2 and CIN 3 that were analyzed as one group (severe neoplasia).
He pointed out that a few studies have assessed that question, and one concluded that interobserver variation is fair to good for the diagnosis of benign conditions, CIN 3, or invasive cancer, but poor for the diagnosis of CIN 1 or CIN 2.
In contrast, among the placebo subjects, HPV 16-related CIN 1 was found in 12, CIN 2 in 7, and CIN 3 in 6 (one woman had CIN 2 at one visit and CIN 3 at another).
a review of the literature from 1950-1992, showed that as much as 60% of CIN 1 lesions regressed, 30% persisted, 10% progressed to CIN 3, and only 1 % progressed to invasive cancer."
(3) Despite evidence that intraepithelial lesions classified as CIN 3 are more likely to progress to invasive cancer and less likely to regress than intraepithelial lesions classified as CIN 2, (4) a CIN 2/3 threshold for excision is still generally retained because the distinction between CIN 2 and CIN 3 is not always clear.
With that in mind, we do believe that prudent providers will follow women of this young age who do not have CIN 3 (which does require treatment).