Infection of HPV 16/18 is estimated to account for more than 80 per cent of invasive cervical cancer including CIN3
and for 50 per cent of CIN2 lesions (52).
Every year, 3,000 to 4,000 women in this age group in England will have CIN3
, according to official records from the Office for National Statistics.
Based on the proposed use, in women aged 25 years and older, the sensitivity of HPV testing for detecting CIN3
or higher was 58.
Failure to develop effective CMI to clear or control infection results in persistent infection and, in the case of the oncogenic HPVs, an increased probability of progression to CIN3
and invasive carcinoma.
Sexual behavior and smoking as determinants of cervical HPV infection and of CIN3
among those infected: a case-control study nested within the Manchester cohort.
Predicting absolute risk of CIN3
during post-colposcopic follow-up: results from the ASCUS-LSIL Triage Study (ALTS).
In the ALTS study, women with ASCUS or LSIL Pap test results and who tested positive for HPV16 in the Roche Diagnostics' HPV Line Blot test had 38 times the risk of developing CIN3
or cervical cancer within 2 years, compared to HPV-negative women in the study.
Type 31 was the most common of the five additional HPV types in the 9-valent vaccine, followed by types 52 and 58, both of which are more frequent in CIN2 than CIN3
Abnormal cell growth in the lower 1/3 of the epithelium is categorized as cervical intraepithelial neoplasia 1 (CIN1); 2/3 of the way from the basal layer as CIN2; and ultimately, when the disorganization extends past 2/3 and reaches the full depth of the epithelium, as CIN3
and CIN2 should be distinguished on histological reports.
The third and most important step of HPV life cycle is its integration into the human genome which is frequently observed in CIN3
or higher lesions.
I had turned 30 The nurse told me the test had found abnormal cells at the CIN3
level, which means the cancerous cells were at the most advanced stage.