CIN3Cervical Intraepithelial Neoplasia 3
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It showed that the S5 DNA methylation test is the best predictor of whether moderate cervical disease will progress to CIN3. The single test performed much better than the methods currently used to monitor existing disease.
FDA recently approved Gardasil's use in adults (male and female), age 27-45, (4) even though Merck's own data found that women who had evidence of current or past HPV 16 or 18 infection before getting the vaccine were 44.6 percent more likely to develop CIN2, CIN3 lesions, or worse compared to the control group.
The combined follow-up in these triple test-negative and test-positive women identified a total of 28 incident CIN3 cases, of which four were detected in triple test-negative women.
Hur et al., "Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients," Nature Communications, vol.
CIN2 cases fell from 896 to 415 (APC, -10.5), and CIN3 from 240 to 0 (APC, -41.3).
(15-17) In a population-based cohort study, Edgren and Sparen (15) evaluated the risk of anal cancer in women with a later history of CIN3 by linking Swedish national registries with cancer registries.
They rated CIN severity by a standard system in which CIN 1 is the least severe form and CIN3 is the most severe.
Literature recommends different methods ranging from simple cytology, colposcopy, and human papilloma virus (HPV ) deoxyribonucleic acid (DNA) testing or even repeat cytology.4-7 Developed world at present relies on cytology screening and treatment of high-grade cervical intra-epithelial neoplasia (CIN2 or CIN3), which is a precursor for cancer.
I was frightened when the doctor explained I had stage 3 (CIN3) precancerous cells which had a high chance of turning cancerous if left.
In the ARTISTIC trial in England 10.9% of cases of CIN2 and 4.3% of CIN3 were HPV negative (15).
The results indicate that HPV testing alone provides greater protection against CIN3 (cervical intraepithelial neoplasia grade 3) and invasive cervical cancer than does cytology alone, and that primary HPV testing provides a similar level of protection against CIN3 and invasive cervical cancer as does cotesting with HPV testing and cytology, according to Roche.