Secondly, the preclinical program expansion indication of PledOx in cellgiftsinducerad peripheral neuropathy (Chemotherapy Induced Peripheral Neuropathy, CIPN
) caused by taxanes.
What brought you to research this particular disease (CIPN
- Why use patients in your CIPN
trial long after they have completed chemotherapy?
It is estimated that in the United States alone there are two m people living with CIPN
and there is no approved therapy for the condition.
Multivitamin use prior to breast cancer diagnosis was associated with significantly lower CIPN
symptoms, while the use of multivitamin supplements during treatment was associated with a marginal decrease.
It is believed that acute oxaliplatin-related CIPN
may be the result of rapid chelation of calcium by oxaliplatin-induced oxalate and that oxaliplatin is able to alter voltage-gated sodium channels, most likely through a pathway involving calcium ions .
NEMUS CEO and CMO, Brian Murphy, said, 'The CIPN
market comprises roughly 1.8 million patients among the major global markets and represents a significant unmet medical need.
Table 1 Alpha, Means, and Standard Deviation Constructs [[alpha].bar] Mean SD Entrepreneurial Orientation (EO) .834 4.32 1.60 Banks' Performance (PF) .74 3.47 .78 Country Institutional Profiles-Regulatory (CIPR) .74 3.63 .63 Country Institutional Profiles-cognitive (CIPC) .67 3.39 .56 Country Institutional Profiles-Normative (CIPN
) .71 3.42 .75 Table 2 Regression Results Regression Dept.
Currently, there are no proven effective drugs for the prevention or treatment of paclitaxel-induced neuropathic pain (PINP) or chemotherapy-induced peripheral neuropathy (CIPN
) in general.
Amiket is a prescription topical cream, a combination of 4% amitriptyline and 2% ketamine, designated to treat chemotherapy-induced peripheral neuropathy (CIPN
) following taxane-based therapy.
Cancer patients can develop a condition called chemotherapy-induced peripheral neuropathy (CIPN
), which is associated with some anti-cancer drugs.