CIRBP

AcronymDefinition
CIRBPCold Inducible RNA Binding Protein
References in periodicals archive ?
As shown in Figure 4, phosphorylated levels of I[kappa]B[alpha] and p65 were markedly downregulated (P<0.01 or P< 0.001) but expression level of Bcl-3 was up-regulated by CIRBP overexpression compared to their controls.
CIRBP, which is the first coldshock protein identified in mammals, was recently identified as a proinflammatory cytokine (22).
Therefore, in our study, we focused on CIRBP and explored its role in transfected H9C2 cells.
The results implied that cell proliferation was promoted by CIRBP overexpression but suppressed by CIRBP knockdown.
In the present study, the ROS level in cells with myocardial ischemia was significantly reduced by CIRBP overexpression while markedly enhanced by CIRBP knockdown.
Thus, we speculated that the influence of CIRBP on cell proliferation and apoptosis might be associated with NF-[kappa]B signaling pathway.
Our study found that overexpression of CIRBP promoted cell proliferation and suppressed cell apoptosis via the NF-[kappa]B signaling pathway.
Effects of cold-inducible RNA-binding protein (CIRBP) on cell viability of H9C2 cells with myocardial ischemia.
Effects of cold-inducible RNA-binding protein (CIRBP) on cell apoptosis of H9C2 cells with myocardial ischemia.
Effects of cold-inducible RNA-binding protein (CIRBP) on reactive oxygen species (ROS) levels of H9C2 cells with myocardial ischemia.