CIRNACalifornia Inland Region of Narcotics Anonymous
CIRNACompagnie d'ingenierie pour les reacteurs sodium
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Recent observations demonstrated that cirNAs are found not only free in blood plasma but also bound to the cell surface (6).
We have found that the main portion of cirNAs in healthy donors is tightly or weakly bound to the cell surface, apparently because of interaction with cell-surface NA-binding proteins (10) or phospholipids of the cellular membrane through bivalent ions (11 ).
As far as cell-surface-bound nucleic acids are concerned, they represent the main part of cirNAs and, along with cirNAs from plasma fraction, provide a valuable source of material for PCR diagnostics (18).