Creutzfeldt-Jakob disease (CJD
) is a fatal brain condition with approximately 100 new cases diagnosed each year in the UK.
Psychiatric symptoms have long been acknowledged as a feature of CJD
. Recent data indicates that psychiatric symptoms occur in 90% to 92% of cases.
"Creutzfeldt-Jakob disease (CJD
) is a rapidly progressive, lethal neurodegenerative disease caused by aggregation of misfolded prion proteins.
"Our finding of infectious prions in skin is important since it not only raises concerns about the potential for disease transmission via common surgeries not involving the brain, but also suggests that skin biopsies and autopsies may enhance pre-mortem and post-mortem CJD
People also have contracted variant CJD
after exposure to BSE-infected cattle.
Two cases of CJD
are presented who were seen at the Shifa International Hospital, Islamabad, Pakistan.
"It is worrying that the CJD
infection of the original patient in question only came to light after surgery, and so the standard procedure for special sterilisation of potentially CJD-infected instruments was not used."
These include Kuru and iatrogenic (medically--acquired) CJD
and Variant CJD
(vCJD) (Ryan, R.
The most common individual misdiagnosis received was viral encephalitis, most likely because of "the multifocality, acuity, and rapidity of symptoms seen in CJD
The federal agency notes that classic CJD
is not related to "mad cow" disease.
The instruments used in the operation were later used in a series of other surgical procedures, with doctors saying it was possible proteins which cause CJD
were not killed by being sterilised.