CKD-EPIChronic Kidney Disease Epidemiology Collaboration
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Therefore, e-GFR estimated by serum cystatin C based CKD-EPI formula is a better option for assessing the renal status in patients of early DKD.
Many advocate that the combined CKD-EPI creatinine-cystatin C equation is the best way to measure GFR.
The MDRD equation has been used more traditionally; however, recent guidelines recommend the newer CKD-EPI equation over the MDRD, and it is becoming more common.
Most clinicians simply use the cystatin C measurements that their laboratory provides in various eGFR equations--such as the Kidney Disease Improving Global Outcomes-recommended CKD-EPI cystatin C eGFR equations (2, 3)--without regard for or knowledge of the standardization status of the laboratory method used.
Today, clinical laboratories customarily calculate eGFR using either the MDRD or CKD-EPI equation whenever a serum creatinine is obtained.
Third, estimating GFR listed as the CKD-EPI equation tends to be less accurate in subjects with normal renal function and CKD than GFR when inulin clearance is used, but is more accurate than serum creatinine or eGFR using the Modification of Diet in Renal Disease (MDRD) formula [14].
CKD-EPI estimates GFR based on age, race, and serum creatinine.
The GFR was measured in 120 patients with chronic systolic heart failure (CHF) using [(125)I] iothalamate clearance (GFR(IOTH)) and estimated using the sMDRD and CKD-EPI equations.
Glomerular filtration rate (GFR) was calculated by CKD-EPI formula for adults and elderly patients, taking into account the data on plasma creatinine level, age and sex of the patient [11, 12, 13].
In an attempt to account for this variation, several serum creatinine-based equations have been developed to estimate GFR, the most notable being the Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), and CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equations for adults and the Schwartz equation for children.
Para la formula habitual se obtiene una media de 50,2[+ o -]20,7 (p<0,001), para la formula de Cockcroft-Gault, de 54,4[+ o -]17,1 (p<0,001), para la formula MDRD, de 69,2[+ o -]22,9 (p<0,001), para la MDRD variable, de 65,17[+ o -]19,2 (p<0,001), para la formula segun la superficie corporal, de 52,9[+ o -]19,3 (p<0,001), y para la formula CKD-EPI, de 40,7[+ o -]20,2 (p<0,001).