Bae, "The p53-p21(Cip1/WAF1) pathway is necessary for cellular senescence induced by the inhibition of protein kinase CKII in human colon cancer cells," Molecules and Cells, vol.
Bae, "MiR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells," Biochemical and Biophysical Research Communications, vol.
GSK3, PKC, PKA, 14-3-3 Mode 1, PKG, p38MAPK, cdk5, CKII, cdc2, ATM, and CKI are the most predicted kinases involved in phosphorylation of many serine and threonine residues in IRS-2.
Meanwhile various kinases such as GSK3, PKC, PKA, ERK, mTOR, S6K, PKG, CDK5, CKII, and JNK are involved in Ser/Thr phosphorylation of IRSs.
Nevertheless, both CKI and CKII
are expressed in each compartment (Grant et al., 1999).
The serine/threonine kinases that catalyze H3T3, H3S10, H3S28, and H4S1 are Haspin, MSK1/MSK2/RSK2, MSK1/MSK2, and CKII
Motifs 7, 8, and 12 represented potential casein kinase II (CKII
) phosphorylation sites (S/TxxD/E) , presented as T[FL]DE, [TQS][LM][GC][GDE], and [ST]AE[EA]; TLGE and TLE[DE]; and TVDE, respectively.
Besides PKC, p47phox can be phosphorylated by many other kinases: PKA , MAP kinases ERK1/2 and p38 , casein kinase 2 (CKII
) , AKT , p21activated kinase (PAK) , src-kinase , and kinase activated by phosphatidic acid (PA) .