42] In renal dysfunction, elimination of CMS is decreased and a greater fraction of the administered dose is converted to colistin; however, a loading dose of 12 MU is still required, but maintenance doses are reduced according to CLcr (Table 2).
5 MU 12-hourly Renal impairment--load with 12 MU, then: * CLCr 20-50: 1-2 MU 8-hourly * CLCr 10-20: 1 MU every 12-18 hours CRRT--full dose; intermittent HD 1 MU 12-hourly and 1 MU after dialysis * Never use colistin as monotherapy MU = million units; CRRT = continuous renal replacement therapy; HD = haemodialysis.
For example: A patient initiating LYRICA therapy for poslherpebc neuralgia with normal renal function (CLcr
[greater than or equal to]60 ml/min), receives a total daily dose of 150 mg/day pregabalin Therefore, a renal impaired patient with a CLcr
of 50 ml/min would receive a total daily dose of 75 mg/day pregabalin administered in two or three divided doses.
The CLcr can be used to estimate the GFR by conducting a 24-hour urine collection.
The CG equation should be used to calculate the CLcr when determining the patient's renal function for the dosing of drugs that are eliminated by the kidneys, as described in the manufacturer's prescribing information.
It is important that clinicians be aware of the differences in estimating GFR using MDRD and CG estimation of CLcr.
000 ASI MI VMR CLCR FI AI RDI Indices ASI Ml VMR CLCR FI AI RDI (1) CDI .
Community Name MI VMR CLCR FI AI RDI Rank Whitehorse 10.
The CLCR and the FI appear to be the strongest predictors, with positive slopes, suggesting that openness and tolerance may play a key role in accumulating high-quality human capital in the North.
Over the last three years, the CFL and CLCR came to the conclusion that the labor movement in general had to play a far more aggressive and sophisticated role in the retention and development of the economy in Chicago--particularly the manufacturing sector.
After years of joint work on small projects, we decided to bring together the 20 years of experience in industrial retention, coalition-building, and strategic vision of CLCR and the enormous political and organizational influence of the CFL, with its 500,000 members and the broad respect it enjoys in the civic, business, and political community.
The CFL and CLCR want to see more companies become organized in the long run, but the immediate objective is for the manufacturing sector to become stronger, more competitive, and more dynamic.