When the differences observed in various domains of CLDQ scores in Group A were compared with those seen in Group B by using independent t-test, the changes in CLDQ-Global score and CLDQ-SY domain score observed in Group B were highly significant [P < 0.
Our study for the first time assessed the quality of life in these patients using CLDQ.
Both the groups were homogenous in their baseline demographic data and in most of the CLDQ scores, which indicate that the two groups were properly randomized [Table 1].
A highly significant improvement in some of the domains of CLDQ scores and in CLDQ-Global score in Group A indicates that standard treatment has to an extent improved the quality of life in these patients.
There was a statistically highly significant change in all the domains of CLDQ and CLDQ-Global score in Group B, which indicates a very good improvement in the quality of life in ALD patients when Vitamin E was added.
In conclusion, supplementation of vitamin E to standard treatment has significantly improved the quality of life in patients with ALD as evidenced by an improvement in the CLDQ scoring.
The present study found a positive correlation between CLDQ scores and family income, implying that those with high family incomes had higher HRQoL, as demonstrated by Hsu et al.
On the other hand, CLDQ values were not related to age, gender, and level of education.
No correlation was observed between MELD and CLDQ scores.
In conclusion, this study found high mean CLDQ scores among a significant number of CLD patients particularly among those with low family income implying low HRQoL.
The authors would like to thank the Coordination of the Improvement of Higher Education Personnel (CAPES), the Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), the Brazilian National Counsel of Technological and Scientific Development (CNPq) for financial support, and Samantha Mucci for providing permission to use the CLDQ questionnaire.