Investigations such as nasopharyngeal aspirates (NPAs) for suspected respiratory infections, blood cultures, chest X-rays, thin/ thick films for malaria parasites, cerebrospinal fluid (CSF), urine, and other samples for microscopy and culture were carried out, on CLWA admitted to hospital, whenever possible.
Overall, 28% and 42% of CLWA on CTX and placebo, respectively, died.
These data provide additional evidence for the protective effect of CTX prophylaxis in CLWA irrespective of the CD4 count and against a background of high antibiotic resistance in Zambia.