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The mean ages for patients with ductal CMBC and SGC were 57 years and 73.6 years, respectively (Table 1).
Comparisons of the IHC staining profiles in the CMBC and SGC groups were performed using a z test to calculate the P values for each IHC stain.
Wallace et al (16) investigated the IHC staining characteristics of 15 cases (from 12 patients) of CMBC and compared them to a series of primary eccrine tumors, including 8 MACs.
We included this study in our review because of its similarity to the current study, even though it focused on distinguishing PBC from SGC, rather than distinguishing CMBC from SGC.
Busam et al (18) studied 30 cases of CMBC compared with 42 primary SGC cases for their expression of ER, PR, and epidermal growth factor receptor (EGFR).
From that limited study, (23) podoplanin appeared to show promise in distinguishing SGC from CMBC.
Although most of the CMBC cases in this study were negative for the basal CK markers, 3 of the 12 cases (25%) were positive for either or both CK5 and CK17.
Table 4 provides a summary of IHC profile staining pattern in CMBC and SGC.
The appearance of a typical CMBC is demonstrated in Figure 3, A, whereas a typical SGC (a PC) is demonstrated in Figure 3, B.
None of the CMBC or SGC tumor cells (0%) demonstrated nuclear staining for PAX5 (as shown in the right inset of Figure 5, B).
If the score was less than 3 of 5 (0, 1, or 2; <60%), the case was defined as CMBC; if it was greater than or equal to 3 of 5 (3, 4, or 5; [greater than or equal to] 60%), it was defined as SGC.
Our study demonstrated a sustained potential of CK5/6 (or CK5 in our study) and p63 in distinguishing CMBC from SGC.
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