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Although both rats and humans metabolized CDEPA to DEA (Figures 8 and 9, respectively), the human liver microsomal arylamidase was more active toward either CDEPA or CMEPA than the rat liver microsomal arylamidase.
CYP2B6 metabolized both alachlor and butachlor to CDEPA, acetochlor to CMEPA, and metolachlor to an unknown metabolite.
In the current study, incubations of the parent herbicides with liver microsomes resulted in major differences between rats and humans in the formation of CDEPA or CMEPA. Our data also indicate that the arylamidase activity in microsomal tissues of both organisms is not rate-limiting with respect to DEA or MEA formation.
For acetochlor, the rate of metabolism to CMEPA by human liver microsomes is approximately one-third the rate observed in rat liver microsomes.
The greater metabolism of acetochlor to CMEPA as compared to the metabolism of alachlor to CDEPA suggests that the methyethyl phenyl group is more readily metabolized than the diethyl phenol group in these pesticides.
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- CMF regimen