"Focusing on the expression level and pattern of cell surface proteins, we observed a sequential differentiation process from granulocyte/monocyte progenitors via cMoPs to pre-monocytes then monocytes that was supported by gene expression studies," corresponding author Toshiaki Ohteki said.
As monocytes give rise to tumor-associated macrophages (TAM), osteoclasts, and colitogenic macrophages, this finding might shed light also on possible therapeutic applications targeting cMoPs and monocytes.
Citation: Shunsuke Kawamura et al., "Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs," Immunity, 2017; 46 (5): 835 DOI: 10.1016/j.immuni.2017.04.019
Also, as a part of the contract award, McKesson will continue to supply pharmaceuticals to over 700 locations, including over 270 medical centres, as well as the VA's seven CMOPs
. The initial two-year contract includes options for up to three, two-year extensions.