CMRNG

Acronym	Definition
CMRNG	Chromosomally-Mediated Resistant Neisseria Gonorrhoeae

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In many countries worldwide, the temporary decrease in the incidence of gonorrhea since the 1980s was accompanied by an increase in the frequency of strains of chromosomally mediated resistant Neisseria gonorrhoeae (CMRNG).1 For example, for the past decade in Japan, there has been a dramatic increase in the prevalence of gonococcal isolates exhibiting chromosomally mediated resistance to penicillin, tetracycline, fluoroquinolones, and oral cephems (1-3).

Our protocol was shown to be a good method for CMRNG detection and genotyping studies.

A novel real-time duplex PCR assay for detecting penA and ponA genotypes in Neisseria gonorrhoeae: comparison with phenotypes determined by the E-Test

Since then, this proportion has continued to increase, and chromosic mediated resistance to penicillin (CMRNG) and tetracycline resistant (TRNG) strains have also become widespread.

Gonorrhea: epidemiology and control strategies

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