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Remarkably, the reference compound cNGR appeared initially to be the most lipophilic compound (-3.30 [+ or -] 0.14).
Although coNGR and co[(NGR).sub.4] were not directly compared with cNGR in an in vivo study, both coNGR-based ligands showed a higher uptake than cNGR in the infarcted area.
Stelt et al., "cNGR: a novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in vivo," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Caption: Figure 2: Structural formulas of DTPA-conjugated coNGR (a), co[(NGR).sub.4] (b), and cNGR (c).
These events provide a policy and historical context for subsequently assessing the current state of the operational reserve and for determining a future course for further development, including how conclusions and recommendations made by the CNGR can continue to assist DOD in implementing an operational National Guard and Reserve.
Let us now turn to the implications of the foregoing for the conclusions and recommendations made by the CNGR in its final report in January 2008.
In response to the report, DOD established a deliberative process for reviewing and assessing the final recommendations of the CNGR and developing responses and positions for the Secretary of Defense to endorse.
In general, however, the conclusions and most recommendations made in the CNGR final report appeared congruent with the developments in policy and practice described above.
The provisions modifying the process for recommending an officer as Chief of the National Guard Bureau concerns a topic which is not addressed in the CNGR report.
For example, instead of addressing the CNGR recommendation to increase the "fully-funded slots allocated to reserve component officers at the National Defense University, senior war colleges, and 10-week [joint professional military education (JPME)] ...
The program itself is only 6 weeks long, which largely eliminates, for this author at least, the argument that Reservists cannot attend because they cannot spare the time away from their civilian positions, though the Marine Corps argued to the contrary in its response to CNGR Recommendation 13.
In my opinion, based on a careful reading of the DOD and Service responses to the CNGR recommendations, as well as my 18 years as a war college faculty member, cultural prejudice still exists between Active Component and Reserve Component personnel, primarily because of misconceptions about, and misunderstanding of, the RC by the AC.
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