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CNQXCyano-Nitroquinoxaline-Dione (pharmacological inhibitor)
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Pressure-applied GABA (200 [micro]M) for 500 msec to pyramidal-shaped BLA neurons, in the presence of CNQX (10 [micro]M), AP-5 (50 [micro]M), and SCH50911 (20 [micro]M), elicited currents that were significantly reduced by 40 [micro]M RDX added to the bath (37 [+ or -] 3% reduction, mean + SE; n = 6; Figure 5).
The glutamate antagonist CNQX blocks the swim motor program elicited by peripheral nerve stimulation
A preliminary study reported that bath application of the non-NMDA glutamate receptor antagonist CNQX blocked the ability of such nerve stimulation to trigger the swim motor program (Brown and Willows, 1993), but the locus of the blocking effect of CNQX was not determined (e.
CNQX blocks monosynaptic EPSPs elicited by S-cell intracellular stimulation
After confirming that CNQX blocks the ability of peripheral nerve stimulation to elicit the swim motor program, we proceeded to more directly test the hypothesis that this occurs, at least in part, by blocking S-cell glutamatergic synapses.
Several studies have shown that the non-NMDA glutamate receptor antagonists DNQX (6,7-dinitroquinoxaline-2,3-dione) and CNQX (6-cyano-7-nitroquinoxaline-2,3-di-one) block sensory neuron transmission in invertebrates (Dale and Kandel, 1993; Trudeau and Castellucci, 1993; Conrad et al.
NMDA antagonist: MK-802, dextromethorphan, ifenprodil, CGS-19755, CNQX, other glutamate inhibitors
The induction mechanisms of the LTP involve both postsynaptically-dependent and -independent mechanisms, as complete block of the postsynaptic response with CNQX and kynurenate blocked LTP induction in only about half the cases (Hochner et al.