Our results in this mouse model of retinitis pigmentosa clearly show that CNTF
treatment can both give life-long protection to cone photoreceptors and preserve useful vision .
The observation that CNTF
is present abundantly in the Schwann cells of peripheral nerves and that it prevents lesion mediated degeneration of motor neurons in post natal rats is compatible with the assumption that CNTF
might also act as a lesion factor making it a candidate for degenerative changes of motor neurons.
A similar tendency was observed in the PLGA 50:50 copolymer matrix, except for 5% CNTF
The ALS CNTF
Treatment Study Phase I-II Study Group (ACTS) (1996).
associate professor of Genetics at the University of Rochester Medical Center, and exposed these precursor cells to two different signaling molecules used to instruct different astrocytic cell fate--BMP (bone morphogenctic protein) or CNTF
(ciliary neurotrophic factor).
is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation.
Alterations in the neurotrophic factors BDNF, GDNF and CNTF
in the regenerating olfactory system.
acts as a survival factor for a variety of neuronal cell types, including sensory, motor, cerebral, hippocampal and hypothalamic magnocellular neurons (MCN).
5A) and CNTF
, EGF, IGFBP4, and BMP6 (other responses, Fig.
LIF junto con CNTF
, FGF1, FGF2, EGF (Factor de Crecimiento Epitelial), Interferon Alfa y Gama son necesarios para la generacion de las celulas madre neuroepiteliales retinianas.
Figure 3C depicts the presence of cytokines/chemokines--including IL-10 and CNTF
, which are immunoregulatory and counteract various aspects of inflammation--in a rat exposed to filtered air and 50 mg/kg 1-NN.
Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF
as a candidate modifier gene.