COAGSColorado Outdoor Adventure Guide School
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Coags Uncomplicated features a Lab Value Analyser that enables physicians to input test results and receive a list of potential diagnoses to consider including a description of each bleeding disorder and typical lab values.
The Coags Uncomplicated app is available for free download at
El componente genetico de algunos de los distintos tipos ha sido demostrado: seis loci (GLCIA-GLC1F) y dos genes (TIGR/MYOC y OPTN) se conocen, hasta ahora, como responsables de la aparicion de glaucomas primarios de angulo abierto tanto del tipo juvenil (JOAG) como de 1 tipo de adultos (COAG).
So far six loci (GLC1A-GLC1F) and two genes (T1GR/MYOC and OPTN) are involved in the development of juvenile (JOAG) and adult onset or chronic primary open angle glaucoma (COAG), while two loci (GLC3A, GLC3B) and one gene (CYP1B1) are known for primary congenital glaucoma (PCG).
Among the POAG, chronic open angle glaucoma (COAG) with an age of onset after the fourth decade of life, accounts for approximately half of all cases.
(2002) discovered four additional variants after screening 54 families with autosomal dominant COAG which had at least one member with normal tension.
A total of 9 families with glaucoma complied with these requirements; seven of them present COAG, one has JOAG and one has PCG.
The first logical step was to rule out CYP1B1 mutations in the PCG family and TIGR/MYOC as well as OPTN mutations in the COAG and JOAG families.
TIGR/MYOC and OPTN were both initially sequenced in one affected patient from each of the COAG families and both individuals with later onset from the PCG family, as well as in a healthy control.
In summary, all of the genes known so far as involved in the pathogenesis of glaucoma can be discarded as the cause of the disease in the COAG patients of Costa Rica.
The linkage analysis with the COAG family disclosed several regions where the gene responsible for glaucoma could potentially be located, but no definite linkage was found.