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Hence, in the present study we first evaluated the prognostic utility of NLR or CEA alone in patients undergoing surgery for CRC and then explored the prognostic value of COCN, a novel inflammation-based prognostic system with tumor characteristics, in an attempt to provide experimental clues for better prediction of CRC prognosis in patients.
Furthermore, according to COCN score as shown in Table 1, patients were assigned into three groups.
The result of univariate analysis showed that tumor stage, NLR, CEA, and COCN were all related to OS and DFS (Table 3).
Moreover, the current study for the first time demonstrated that COCN was more effective candidate prognostic biomarker in patients undergoing surgical resection of CRC than NLR or CEA alone.
As shown in Table 4, COCN was an independent prognostic biomarker.
Our study demonstrated that COCN was correlated with survival of patients with resected primary CRC and supported the categorization of CRC patients into groups as favorable or poor prognosis based on the combined detection of inflammation-based and tumor-related factors.
Despite these limitations, still our study suggests that COCN was proved to be a better independent prognostic biomarker of CRC than NLR or CEA alone.
In summary, our research showed COCN to be an independent prognostic biomarker for CRC.
Caption: Figure 1: Receiver operating characteristics curve analysis of NLR, CEA, and COCN in CRC patients.
(e) OS according to COCN. (f) DFS according to COCN.