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COL3A1Collagen, Type III, Alpha1
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Moreover, the study confirmed the final effector molecules under negative regulation by miR-29 were COL1A1 , COL1A2 , and COL3A1 .
The primary objective of our study was to determine whether COL3A1 rs1800255 and COL12A1 rs970547, like COL5A1 rs12722 and COL6A1 rs3579 6750, are associated with athletic endurance performance in the participants of four SA Ironman triathlon events.
The secondary objective was to investigate gene-gene interactions between COL3A1 rs1800255 and COL12A1 rs970547, and previously associated collagen genes where appropriate, and endurance performance.
Genotyping of COL3A1 rs1800255 was performed using a customdesigned, fluorescence-based Taqman polymerase chain reaction (PCR) assay (Applied Biosystems, USA).
No genotype effects were identified between any of the participant characteristics and the COL3A1 rs1800255 or COL12A1 rs970547 variants (data not shown).
Following the demonstration of the growth inhibitory effect of TQ on LX2 cells, we went on to further examine the effect of TQ on the mRNA expression of several fibrosis-related genes including COL1 Al, COL3A1, and a-SMA in both LX2 and culture-activated primary rat HSCs.
To examine the effect of TQ on transactivation, freshly isolated rat HSCs were cultured for 7 days in the presence or absence of TQ and the mRNA expression levels of COL1 Al, COL3A1 and a-SMA genes were determined via qRT-PCR.
In addition to blocking the transactivation of quiescent HSCs, TQ significantly inhibited the fibrogenic activity in fully activated cells: TQ-treated LX2 cells showed significantly reduced mRNA expression levels of COL1A1 and COL3A1 compared to vehicle-treated cells.
The clinical diagnosis can be confirmed by fibroblast culture from a skin biopsy to detect abnormal type III collagen or by detection of a mutation in the COL3A1 gene (2).
The expression of type I and III collagens COL1A1 and COL3A1, and tissue inhibitor of metalloproteinases, TIMP-1 were up-regulated by NF3 significantly, while the expression of MMP-9 gene was down-regulated by NF3 (Fig.
Our results showed that the expression of COL1A1 and COL3A1 were up-regulated by NF3 in fibroblast Hs27 cells (Figs.
Abbreviations: BMP6, bone morphogenetic protein 6; COL1A1, collagen, type I, alpha 1; COL3A1, collagen, type Ill, alpha 1: MAPK, mitogen-activated protein kinases; MMP-9, matrix metalloproteinase 9; TIMP-1, a tissue inhibitor of metalloproteinases 1; TGF-[beta]1, transformation growth factor pl.