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The BCVA (logMAR) was 0.21 [+ or -] 0.17 and 0.19 [+ or -] 0.14 at initial stage, 0.24 [+ or -] 0.23 and 0.22 [+ or -] 0.18 at 6 weeks, 0.24 [+ or -] 0.18 and 0.21 [+ or -] 0.18 at 10 weeks, 0.28 [+ or -] 0.21 and 0.25 [+ or -] 0.17 at 18 weeks, and 0.24 [+ or -] 0.19 and 0.22 [+ or -] 0.16 at 30 weeks in the Conv group and SPL group, respectively.
Through the observational periods, no onsets of NVI and NVG occurred; however, 1 case of vitreous hemorrhage was noticed in each group (the Conv group: at 29 weeks after PRP, the SPL group: at 30 weeks after PRP) (Table 3).
As described in the Methods section, we performed PRP 500 shots in the eyes of the pigmented rabbits in the Conv 500s group using the conventional argon laser, 500 shots in the SPL 500s group, and 1000 shots in the SPL 1000s group using PASCAL photocoagulator (Figure 3).
VEGF levels in the Conv 500s group increased from a baseline (before PRP) of 7.3 [+ or -] 3.9pg/mL to 59.7 [+ or -] 14.1pg/mL, then decreased to 41.7 [+ or -] 18.2 pg/mL after 7 days and 24.5 [+ or -] 10.5 pg/mL after 14 days.
IL-6 levels in SPL 500s group were significantly lower at day 1 (p = 0.0065), day 7 (p = 0.016), and day 14 (p = 0.0039) than those in the Conv 500s group, whereas the significant difference between the Conv 500s group and the SPL 1000s group was noticed only at day 1 (p = 0.048).