Since 2012, a newly emerged human pathogenic coronavirus (CoV
) has caused an ongoing epidemic on the Arabian Peninsula.
21, 19Dam) sampled on December 30 were reinfections, as has been reported for other CoVs
Middle East respiratory syndrome (MERS) is a pneumonic illness caused by a novel lineage C beta-coronavirus (CoV
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel CoV
known to cause severe acute respiratory illness in humans; [approximately equal to] 40% of confirmed cases have been fatal.
However, because of conserved features of nonstructural proteins among even distantly related CoVs
(7,12), cross-reactivity was possible with this assay (15).
The incidence of infection with the causative agent, a betacoronavirus (MERS CoV
) (1), has not been determined; however, the mortality rate among those who received clinical care is [approximately equal to] 65% (2).
The amino acid sequences of viruses from Nycteris bats in Ghana (3) and the 2c prototype bat CoVs
, HKU4 and HKU5, from China (6) differed by 5.5%-7.7% from MERS-CoV.
The spike proteins of CoVs
are responsible for receptor binding and host species adaptation, and their genes therefore constitute one of the most variable regions within CoV
Using this more specific and sensitive assay, we detected viral RNA in 63% of the rectal swabs tested; other CoVs
including FIPV, severe acute respiratory syndrome-CoV, and human CoV
NL63, were not amplified by this assay (data not shown).
In this study, we detected bat CoVs
in the Philippines.
In contrast, other genetically similar CoVs
were detected in several different bat species.