COX-2


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Related to COX-2: Cox-1
AcronymDefinition
COX-2Cyclooxygenase 2
References in periodicals archive ?
Selective COX-2 inhibitors could induce severe coronary vasospasm through unbalanced COX inhibition.
In this research work, COX-2 expression has been studied immunohistochemically in colorectal cancer and its expression has been tried to correlate with grade of these tumours, so that this study could add to what we already know about the importance of COX-2 and its association with colorectal cancer and its pathogenesis.
COX-2 synthesizes prostaglandin E2 (PGE2), which operates in PGE2 and PGE4 endothelial cell receptors.
MK801 (Sigma Chemical, St Louis, MO, USA; 0.01, 0.1, 1 [micro]M), a NMDA receptor antagonist; NS398 (1, 10, and 100 [micro]M), a COX-2 selective inhibitor; DKK-1 (R&D Systems; 10, 50, 100ng/ml), a Wnt/[beta]-catenin signaling inhibitor; and bevacizumab (0.25, 2.5, and 25mg/ml), an anti-VEGF antibody were intravitreally injected with the 80 nmol NMDA in some rats.
COX-2, BRCA1, feline, mammary tumor, gene expression
Material and Methods: Serum IL-6 and COX-2 levels were determined by ELISA.
Age, breed, tumor location, stage, surgical margins, diagnosis, COX-2 score, and treatment duration with selective COX-2 inhibitor for each patient are listed in table 1.
Another gene cyclooxygenase-2 (COX-2) synthesizes prostaglandins which participate in arachidonic acid metabolism resulting in various mechanisms that leads to cancer development.
Results: The positive rates of COX-2 in normal group, neoplastic group and cancer groups were 3.3%, 21.7% and 55.0% respectively.
The results showed that of those currently using a COX-2 inhibitor, 19% were more likely to die after a stroke than those who didn't take the drug and new users of the medicines had a 42% increase in risk mortality from stroke compared to nonusers.