CPCRACommunity Programs for Clinical Research on AIDS
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This article was assembled with the use of data provided by the Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) (National Institutes of Health, National Institute of Allergies and Infectious Diseases, Contract Numbers Y01-AI-0002, Y01-A1-4040, and Y1-AI-0431), and the author thanks the CPCRA for its early support and willingness to share data from the CPCRA 012 and CPCRA 006 studies.
The CPCRA studies that have documented comparatively poorer survival for women have suggested that differential health care access or socioeconomic status may play a role in these findings.
In a CPCRA study of more than 4,500 people with HIV, HIV-infected women were one-third more likely than HIV-infected men to die within the study period.
CPCRA (Winter 2002 Group Meeting of the Terry Beirn Community Programs for Clinical Research on AIDS), November 16-18, Washington DC, http://www.
Study CPCRA 039 - This Phase III study is being conducted by the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID).
Then an Executive Board, a Scientific Advisory Committee, and a Community Advisory Forum were all established in 1988 (the year before the CPCRA was started).
22,26,27) The data are also mixed regarding multi-drug-experienced patients; however, the CPCRA 064 study observed significantly more cases of disease progression in the STI group, compared to the control group.
Clinically, patients may be better off staying on treatment, as shown by the CPCRA 064 study recently reported by Jody Lawrence and her co-investigators (see data review, page 5).
In the CPCRA Phase III study, patients will be randomized to receive either GS 840 (one 120 mg tablet) or placebo, in addition to their current antiretroviral therapy, including combination regimens.
It's moving away from drug development-type trials," said Jim Neaton, a CPCRA biostatistician and principal investigator of the ESPRIT IL-2 trial.
The National Institutes of Health has called upon the research consortiums it funds, including CPCRA, to design trials that evaluate strategic approaches to the use of anti-HIV drugs.
This estimate is based on the CPCRA NvR study, which had a study population with more advanced disease at entry.