CPEB


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AcronymDefinition
CPEBCytoplasmic Polyadenylation Element Binding (RNA binding protein)
CPEBCentral Physical Evaluation Board
CPEBCarl Philip Emmanuel Bach (classical composer)
References in periodicals archive ?
These oligomers have a hardy resistance to ordinary solvents, and within neurons may be much more stable than single-copy "monomers" of CPEB.
In the new study, Si and his colleagues examined a Drosophila fruit fly CPEB protein known as Orb2.
Tras la senal activadora una proteina quinasa (Eg2-observaciones hechas en Xenopus laevis una especie de rana usada en la investigacion en genetica, en invertebrados podria ser otra proteina quinasa MAPK) fosforila a la CPEB en la serina 174; la CPEB se encuentra unida al elemento de poliadenilacion citoplasmatico-CPE (secuencia concenso UUUUUAUU) en el extremo 3'UTR cerca de la senal de poliadenilacion AAUAAA-senal de poliadenilacion.
La CPEB en Aplysia regula la sintesis de proteinas de manera sinapsis especifica estabilizando los procesos de facilitacion a largo plazo.
La CPEB activa (en su forma de prion) podria permanecer fisicamente (por ejemplo una barrera electromagnetica) secuestrada en la neurita, de escapar podria desencadenar reacciones en otros lugares de la neurona que harian perder la fidelidad de la informacion.
En el hombre la proteina CPEB implicada en la regulacion de la traduccion del ARNm ha sido caracterizada como una proteina con propiedades similares a los priones.
A neuronal isoform of the aplysia CPEB has prion-like properties.
Making proteins at the synapse: activity-regulated translation and CPEB.
N-methy1-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses.
Abbreviations: AMPA, alpha-amino-3-hydroxy-5-methyl-4-isox-azolepropionic acid; AMPAR, AMPA receptor; C/EBP, CCAAT-box-enhanced binding protein; CamKII, calcium/calmodulin-dependent protein kinase type II; CPEB, cytoplasmic polyadenylation element binding protein; CRE, cAMP-responsive element; CREB, cAMP response element binding protein; CS, conditioned stimulus; EPSP, excitatory postsynaptic potential; LTF, long-term facilitation; LTP, long-term potentiation; MAPK, mitogen-activated protein kinase; NMDA, N-methyl-D-aspartate; PKA, protein kinase A; PKC, protein kinase C; PSP, postsynaptic potential; STF, short-term facilitation.
When CPEB can change into amyloid form, neurons make long-lasting connections.