As both CPRL
and CPR were under the control of CPL, the transaction will be accounted for in a manner similar to a pooling-of-interests and the historical financial information of CPR will become the historical financial information of newly formed CPRL
It is important to emphasize that neither the NGSP CPRL
method nor the IFCC method is suitable for routine measurement of Hb A1c in patient samples.
1c]; DCM, Designated Comparison Method; NGSP, National Glycohemoglobin Standardization Program; JDS, Japanese Diabetes Society; NRL, Network of Reference Measurement Laboratories; DCCT, Diabetes Control and Complications Trial; CPRL
, Central Primary Reference Laboratory; PRL, Primary Reference Laboratory; SRL, Secondary Reference Laboratory; and JSCC, Japanese Society of Clinical Chemistry.
PRLs serve as back-up laboratories for the CPRL to ensure that the CPRL function would continue without interruption in the event that the CPRL could not meet the program needs.
SRLs must be certified as traceable to the CPRL method according to specific, strict criteria (see "Certification Criteria" below).
A proposed network laboratory (PRL or SRL) must perform precision testing according to NCCLS EP5-A guidelines (14) and participate in a fresh-blood sample comparison (n = 100) for estimation of bias from the CPRL according to modified NCCLS EP9-A guidelines (15).
Monthly surveys are administered by the CPRL to monitor performance of the network PRLs and SRLs.
PRLs and SRLs must fulfill the following criteria for network laboratory certification: (a) total imprecision (CV) must not be significantly ([chi square] analysis) >3%; (b) no more than one within-method and one between-method outlier is acceptable; and (c) the 95% confidence interval (CI) for predicted bias should overlap the [+ or -] 3% range of the CPRL at two GHB concentrations (6% and 9% Hb[A.
Under the terms of the agreement, Ciphergen will provide instrumentation, biochip arrays and software that the NCI CPRL will use to study biomarker patterns indicative of ovarian cancer.
At the annual meeting of the Association for Laboratory Automation in February 2005, the NCI CPRL presented results of a study of ovarian cancer sera with total inter-day precision of 6-12% based on the use of the ProteinChip System, PBSIIc which is the predecessor system to the Series 4000.
Actual results may differ materially from those projected in such forward-looking statements due to various factors, including the possibility that assays developed by the CPRL may fail to validate in larger studies as providing an accurate diagnostic for ovarian cancer, the ProteinChip technology's ability to validate and/or develop protein biomarkers as novel drug targets, diagnostic or toxicology assays, and the Company's ability to successfully commercialize such tests.
We are excited to be working with the NCI CPRL on this important project," said Gail S.