CRHR1Corticotropin-Releasing Hormone Receptor 1
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Corticosteroid pharmacogenetics: Association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids.
(43) Studies with transgenic mice showed that ethanol enhanced the activity of CRHR1 receptors in the CeA, implicating potential cell type--specific interactions between the stress corticotropin releasing hormone (CRH) signaling pathway and alcohol consumption and dependence.
In corticotrophshypophyse cells, CRH binds to CRHR1 and stimulates the transcription of the POMC gene.
Yang et al., "Corticotrophin-releasing hormone type 1 receptor gene (CRHR1) variants predict posttraumatic stress disorder onset and course in pediatric injury patients, "Disease Markers, vol.
The NR3C1, CRHR1, and AVPRlb polymorphisms were genotyped using TaqMan SNP Genotyping assays (Applied Biosystems) and TaqMan Genotyping Master Mix.
CRH production in the amygdala increases with chronic alcohol administration, resulting in long-term upregulation of CRHR1 gene expression in specific regions of the brain.
Wolf et al., "Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling," Neurobiology of Disease, vol.
Differential expression of CRH, UCN, CRHR1 and CRHR2 in eutopic and ectopic endometrium of women with endometriosis.
Chen and colleagues (2010) reported significant associations between the P3 amplitude to visual targets as well as to alcohol dependence diagnosis with multiple single nucleotide polymorphisms (SNPs) in the cordcotrophin-releasing hormone receptor 1 (CRHR1) gene, which has been shown to have a role in the environmental stress response in ethanol self-administration animal models.
One study of at-risk children found an interaction between a particular genetic variant coding for the CRF receptor (i.e., CRHR1) and sexual trauma in adolescents that predicted an earlier age of onset of drinking and heavy alcohol consumption (Blomeyer et al.
Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-olds.
Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples.