CRM1

AcronymDefinition
CRM1Chromosome Region Maintenance
Copyright 1988-2018 AcronymFinder.com, All rights reserved.
References in periodicals archive ?
CRM1 is a securitisation of Dutch prime residential mortgages, with the majority originated by GE Artesia prior to 2008.
[66] failed to observe an inhibition of the accumulation of HuR in the cytoplasm of HSC3 and Ca9-22 cell lines after 7 h of treatment with LMB, suggesting that in OSCCs, HuR is exported to the cytoplasm in a manner different from that of normal cells (CRM1 independent).
Martignetti, MD, PhD, Associate Professor of Genetics and Genomic Sciences and Oncological Sciences at Mount Sinai, in collaboration with investigators at Karyopharm Therapeutics, inhibited a nuclear shuttle protein called exportin 1 (XPO1, also called CRM1) using a novel class of drugs called a selective inhibitor of nuclear export (SINE) that can be taken by mouth.
OXS1 protein accumulates in the nucleus during stress, and nuclear exclusion in the absence of stress requires Crm1 (exportin1).
Dynatem has introduced its Intel Pentium M-based CRM1 which supports an x86 processor that is suited for embedded, rugged applications with its low power consumption.
Additional proteins such as RanGTP and CRM1 are essential mediators for this "nuclear-cytoplasmic shuttling" of p53 protein (83).
Selinexor functions by binding with and inhibiting the nuclear export protein XPO1 (also called CRM1), leading to the accumulation of tumor suppressor proteins in the cell nucleus, which subsequently reinitiates and amplifies their tumor suppressor function.
Fagerlund and colleagues have presented strong evidence in their study to suggest that importins [alpha]3 and [alpha]4 are responsible for the translocation of TNF-[alpha]-stimulated active subunits of NF-[kappa]B to the nucleus from the cytoplasm [25] and the subsequent export back into the cytoplasm with the support of exportin, CRM1 (chromosome region maintenance 1) [26, 27].
Selinexor functions by binding with and inhibiting the nuclear export protein XPO1 (CRM1), leading to the accumulation of tumor suppressor proteins in the cell nucleus, which subsequently reinitiates and amplifies their tumor suppressor function.
Lo, "Role of ERK MAP kinase and CRM1 in IL-1[beta]-stimulated release of HMGB1 from cortical astrocytes," GLIA, vol.
Selinexor functions by inhibiting the nuclear export protein XPO1 (also called CRM1), leading to the accumulation of tumor suppressor proteins in the cell nucleus, which subsequently reinitiates and amplifies their tumor suppressor function.
Selinexor functions by binding with the nuclear export protein XPO1 (also called CRM1), leading to the accumulation of tumor suppressor proteins in the cell nucleus, which subsequently reinitiates and amplifies their tumor suppressor function, leading to the selective induction of apoptosis in cancer cells, while largely sparing normal cells, concluded the company.