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The round-robin trials were also used to assess the performance of the cRMLs in a network.
The measurements of the frozen samples by the four cRMLs enabled the assignment of total [T.sub.4] target values and the estimation of individual measurement uncertainties.
On the other hand, with respect to the number of 1-mL aliquots of the single-donation sera, the diagnostics industry should realize that these materials are available only in limited stock sizes (the certification process with the cRMLs and the stability study consumed ~90 of the 150 mL that was the maximum obtained per donation).
The outcome of the internal accuracy control further shows that the cRMLs were able to maintain the accuracy of their performance over a longer period with fulfillment of the 0.9% limit for systematic deviation.
Although the between-laboratory variation might again be explained by small differences in the skill levels in the individual cRMLs, the most probable cause lies in small systematic differences in the measurement procedures (e.g., degree of sample purification, chromatographic, and MS resolution).
However, because it is foreseeable that the needed RML capacity will be high in the near future, a second mechanism is required to ensure that different cRMLs perform at the same level of analytical quality.
Different variants of ID-MS cRMPs are now available and are performed with predefined analytical specifications in four cRMLs organized in a network.
On average, 7-10 measurement series were needed by each cRML to complete the duplicate measurements of the frozen sera.
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- CRMP3-associated molecule