Also found in: Medical.
CRMP5Collapsin Response Mediator Protein 5
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
The collapsin response mediator protein (CRMP) family is composed of five cytosolic phosphoproteins (CRMP1 to CRMP5) that are highly expressed in the developing nervous system.[sup][7],[8] CRMP2 is the first member of this family to be discovered and has been studied most frequently.
(3,5,6,10,11) The other causes are neurologic (multiple sclerosis and acute disseminated encephalomyelitis, for example), traumatic, infectious (such as human T-lymphotrophic virus-1, HIV, tuberculosis, and syphilis), vascular (acute spinal cord infarction), nutritional deficiencies (copper and Vitamin B12, for example), and paraneoplastic causes--those who have collapsing response mediator protein 5 (CRMP5) also known as CV2 in particular (5,6); ampiphysin-IgG, which is known to be commonly associated with small cell lung cancer and breast cancer, had reportedly been detected in the sera of patients with rapidly progressive myelopathy and LETM on imaging.
These antibodies are directed against two categories of antigens: (1) intracellular antigens (Hu, Ma2, CRMP5, amphiphysin, etc.) and (2) cell surface antigens (the VGKC complex, NMDAR, AMPARs, GABABRs, mGluR5 receptor, GlyRs, etc.).