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The company applies its pioneering expertise in hypoxia-inducible factor (HIF), connective tissue growth factor (CTGF) biology, and clinical development to advance innovative medicines for the treatment of anemia, fibrotic disease, and cancer.
Western Blot Analysis of iNOS, CTGF, [alpha]-SMA, and FN Expression.
Rodriguez Vita et al., "Connective tissue growth factor (CTGF): a key factor in the onset and progression of kidney damage," Nefrologia, vol.
Moreover, the mRNA expression levels of fibrotic markers, such as TGF-[beta], PDGFB, CTGF, fibronectin 1, and collagen 1A1, increase significantly in kidneys of these mice.
A previous study reported that promotion of MET and reversal of EMT could relieve liver fibrosis. EMT and MET were also demonstrated to be involved in the fibrosis of pelvic endometriosis, conversion of endometriotic stromal cells into myofibroblasts, and the upregulation of a-SMA and collagen I. Notably, the Hippo signaling pathway was also demonstrated to play a role in the development and progression of endometriosis, which modulates endometrial stromal cell activity through transcriptional regulation of CTGF.
Oostendorp, Stroma-derived connective tissue growth factor (CTGF) maintains cell cycle progression and repopulation activity of hematopoietic stem cells in vitro, Stem Cell Reports, October 29, 2015.
In addition to CD31 and vimentin, fibrosis activation was also obvious in TGF-[beta]1 group as noted by the elevated mRNA level of [alpha]-SMA, collagen I, collagen III, CTGF, and Fn (Figures 3(c)-3(g)).
Proteins were detected by monoclonal primary antibodies against sodium hydrogen exchanger (NHE-1), nephrin, connective tissue growth factor (CTGF), fibronectin (FN), [alpha]-smooth muscle actin (SMA), NOX-4, and GAPDH (Sigma, USA); the latter was used to ensure equal loading of samples.
The N-terminal probrain natriuretic peptide (NT-proBNP) assay kit, matrix metalloproteinase-9 (MMP-9) assay kit, connective tissue growth factor (CTGF) assay kit, and transforming growth factor-beta 1 (TGF-[beta]1) assay kit were purchased from Uscn Life Science Inc.
Connective tissue growth factor (CTGF) is a key molecule involved in the development and progression of fibrosis by promoting the synthesis of ECM proteins including collagen.
This reduction was accompanied by a decreased production of CTGF and TGF-[beta] (Figure 5A, B, E and F: percentage of positive cells for CIH vs CIHAng: CTGF=54.7 [+ or -] 4.22 vs 17.8 [+ or -]1.77%, P< 0.0001; IOD: TGF-[beta]=20,906.0[+ or -] 5220.9 vs 8275.4 [+ or -] 629.2, P< 0.0001, respectively).
One of these, called CTGF or connective tissue growth factor, was intriguing because its levels rose in the supporting cells, or glia, that formed the bridge in the first two weeks following injury.
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