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Results of qualitative rapid assays for CK-MB, myoglobin, and cTnI before and sequentially after the 1997 Boston Marathon are shown in Table 1 with positive tests confirmed by corresponding reference methods.
 Nonstandard abbreviations: CK-MB, creatine kinase-muscle-brain; cTnT, cardiac troponin T; cTnI, cardiac troponin I.
Results: Doxorubicin produced severe cardiotoxicity confirmed by markedly raised serum levels of cTnI CK- MB LDH and grade 3 necrosis of the heart tissue in rabbits.
On returning to the United States, she again experienced chest pain and was admitted to the hospital with a cTnI result of 6.2 [micro]g/L.
The cTnI and cTnT assays were performed at the same time when all the specimens from the same patient were available (ie, within 1 week from collection at most) with interim storage at -25 [degrees] C.
The test is a quantitative fluorescent 1-step sandwich immunoassay developed to measure human cTnI concentrations in separated EDTA plasma (5).
When measured at the time of arrival in the emergency department (ED) , hscTnI had a similar specificity to cTnI (86.9% for hs-cTnI vs 84.4% for cTnI).
 Nonstandard abbreviation: cTnI, cardiac troponin I.
Our goals were (a) to compare the diagnostic performance of an investigational hs-cTnI assay used in clinical practice globally outside the US to a contemporary cTnI assay used in US clinical practice for the diagnosis of type 1 MI (T1MI) and type 2 MI (T2MI) by use of cTn measurements alone and in combination with a normal 12-lead electrocardiogram (ECG), and (b) to determine the optimal deltas (serial cTnI concentration changes) for each assay.
The disposition and costs for patients in each decision model for cTnI can be seen in Table 5.
The classification of patients as non-ST elevation myocardial infarction (NSTEMI) or unstable angina pectoris (UAP) was based on clinical judgment, electrocardiography (ECG) recordings, and rise and/or fall of cTn concentrations as measured by contemporary sensitive assays (both cTnT and cTnI) used in 2007-2008 in the hospitals in the catchment area of the coronary care center.
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