CTNiChristian Television Network International (West Palm Beach, FL)
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Results of qualitative rapid assays for CK-MB, myoglobin, and cTnI before and sequentially after the 1997 Boston Marathon are shown in Table 1 with positive tests confirmed by corresponding reference methods.
[3] Nonstandard abbreviations: CK-MB, creatine kinase-muscle-brain; cTnT, cardiac troponin T; cTnI, cardiac troponin I.
Results: Doxorubicin produced severe cardiotoxicity confirmed by markedly raised serum levels of cTnI CK- MB LDH and grade 3 necrosis of the heart tissue in rabbits.
On returning to the United States, she again experienced chest pain and was admitted to the hospital with a cTnI result of 6.2 [micro]g/L.
The cTnI and cTnT assays were performed at the same time when all the specimens from the same patient were available (ie, within 1 week from collection at most) with interim storage at -25 [degrees] C.
The test is a quantitative fluorescent 1-step sandwich immunoassay developed to measure human cTnI concentrations in separated EDTA plasma (5).
When measured at the time of arrival in the emergency department (ED) [4], hscTnI had a similar specificity to cTnI (86.9% for hs-cTnI vs 84.4% for cTnI).
[2] Nonstandard abbreviation: cTnI, cardiac troponin I.
Our goals were (a) to compare the diagnostic performance of an investigational hs-cTnI assay used in clinical practice globally outside the US to a contemporary cTnI assay used in US clinical practice for the diagnosis of type 1 MI (T1MI) and type 2 MI (T2MI) by use of cTn measurements alone and in combination with a normal 12-lead electrocardiogram (ECG), and (b) to determine the optimal deltas (serial cTnI concentration changes) for each assay.
The classification of patients as non-ST elevation myocardial infarction (NSTEMI) or unstable angina pectoris (UAP) was based on clinical judgment, electrocardiography (ECG) recordings, and rise and/or fall of cTn concentrations as measured by contemporary sensitive assays (both cTnT and cTnI) used in 2007-2008 in the hospitals in the catchment area of the coronary care center.