verify regulation of CTR1
and CUP1 using quantitative PCR.
Assinder, "The mammalian copper transporters CTR1
and CTR2 and their roles in development and disease," The International Journal of Biochemistry & Cell Biology, vol.
Treatment with curcumin or U0126, a specific MAPK inhibitor, or suppression of cellular uptake of copper by siRNA knockdown of copper transporter protein 1 (CTR1
) blocked copper-induced cell proliferation.
Copper deprivation modulates CTR1
and CUP1 expression and enhances cisplatin cytotoxicity in Saccharomyces cerevisiae.
Gitschier, "The copper transporter CTR1
provides an essential function in mammalian embryonic development," Proceedings of the National Academy of Sciences of the United States of America, vol.
IFN[gamma] stimulation also increased Cu uptake and elevated expression of the CTR1
Cu importer .
A common phenomenon of MDR phenotypic cancer cells is their capability to expel the drugs mediated by ATP-dependent membrane transporter P- glycoproteins (P-gp)  and also decreased drug uptake facilitated by down regulation of copper transporter (CTR1
Dietary copper is absorbed into enterocytes of the stomach and duodenum via the CTR1
copper import protein and possibly via DMT1 (divalent metal transporter 1) or other less well-characterized transmembrane routes (9).
Reducao da quantidade de alimento g [tratamento.sup.-1] % Controle 186,2 [+ or -] 1,8a 0 5A/2R 144,8 [+ or -] 9,0 b 22,54 4A/3R 118,1 [+ or -] 6,5 c 36,57 (1) Media [+ or -] desvio padrao.
Here, copper is reduced to cupric state and transported across plasma membrane by CTR1
transporters as described later.