Interestingly, it was revealed that circulating CTRP1 levels were positively correlated with circulating FGF21 levels.
showed that circulating CTRP1 levels are elevated in Chinese subjects with T2DM and independently correlated with T2DM risk factors including BMI, fasting blood glucose levels, HbA1c, LDL cholesterol, and TNF-[alpha] .
The previous studies reported that the administration of recombinant CTRP1 decreases blood glucose levels through activating the AMPK pathway and facilitating glucose uptake in the skeletal muscles in mice and that CTRP1 transgenic mice show an improved metabolic index against a high-fat diet .
In the point of view that both circulating CTRP1 and FGF21 levels are increased in subjects with T2DM, the functional relationship between CTRP1 and FGF21 would be expected.
In conclusion, this study shows the relationship between CTRP1 and FGF21.
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Caption: Figure 1: Circulating CTRP1 levels in healthy subjects and subjects with DM.