CTRP1C1q TNF (Tumor Necrosis Factor)-Related Protein 1
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Interestingly, it was revealed that circulating CTRP1 levels were positively correlated with circulating FGF21 levels.
showed that circulating CTRP1 levels are elevated in Chinese subjects with T2DM and independently correlated with T2DM risk factors including BMI, fasting blood glucose levels, HbA1c, LDL cholesterol, and TNF-[alpha] [12].
The previous studies reported that the administration of recombinant CTRP1 decreases blood glucose levels through activating the AMPK pathway and facilitating glucose uptake in the skeletal muscles in mice and that CTRP1 transgenic mice show an improved metabolic index against a high-fat diet [10].
In the point of view that both circulating CTRP1 and FGF21 levels are increased in subjects with T2DM, the functional relationship between CTRP1 and FGF21 would be expected.
In conclusion, this study shows the relationship between CTRP1 and FGF21.
Increased serum level of CTRP1 is associated with low coronary collateralization in stable angina patients with chronic total occlusion," International Journal of Cardiology, vol.
Elevated circulating levels of CTRP1, a novel adipokine, in diabetic patients," Endocrine Journal, vol.
Circulating level of CTRP1 in patients with nonalcoholic fatty liver disease (NAFLD): is it through insulin resistance?
Adamcova, "Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1: a pilot study: measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome," Clinical Biochemistry, vol.
Tumor necrosis factoria and interleukin-1[beta] increases CTRP1 expression in adipose tissue," FEBS Letters, vol.
Caption: Figure 1: Circulating CTRP1 levels in healthy subjects and subjects with DM.