CTRP1C1q TNF (Tumor Necrosis Factor)-Related Protein 1
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The previous studies reported that the administration of recombinant CTRP1 decreases blood glucose levels through activating the AMPK pathway and facilitating glucose uptake in the skeletal muscles in mice and that CTRP1 transgenic mice show an improved metabolic index against a high-fat diet [10].
In the point of view that both circulating CTRP1 and FGF21 levels are increased in subjects with T2DM, the functional relationship between CTRP1 and FGF21 would be expected.
In conclusion, this study shows the relationship between CTRP1 and FGF21.
Liu et al., "Increased serum level of CTRP1 is associated with low coronary collateralization in stable angina patients with chronic total occlusion," International Journal of Cardiology, vol.
Wang et al., "Elevated circulating levels of CTRP1, a novel adipokine, in diabetic patients," Endocrine Journal, vol.
Beigy et al., "Circulating level of CTRP1 in patients with nonalcoholic fatty liver disease (NAFLD): is it through insulin resistance?" PLoS ONE, vol.
Adamcova, "Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1: a pilot study: measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome," Clinical Biochemistry, vol.
Kim et al., "Tumor necrosis factoria and interleukin-1[beta] increases CTRP1 expression in adipose tissue," FEBS Letters, vol.
Sato et al., "A novel adipokine C1q/TNF-related protein 1 (CTRP1) regulates chondrocyte proliferation and maturation through the ERK1/2 signaling pathway," Molecular and Cellular Endocrinology, vol.
Caption: Figure 1: Circulating CTRP1 levels in healthy subjects and subjects with DM.