Independent variables including age, education, baseline cognitive test scores (MMSE, ADAS-Cog, delayed recall, CVFT, digit span, visual span), functional assessment (DAD), mood (NPI depression) scores, CVRF scores, CIRS scores, and duration of depression were entered into the regression analysis.
According to the regression analyses, a diagnosis of depression, as well as lower baseline CVFT and MMSE scores predicted a higher risk of CDR decline in subjects with baseline CDR scores of 0.
Wald p Value Exp(B) 95% Confidence interval for Exp(B) MMSE 9.68 0.002 0.73 0.60-0.89 CVFT 5.25 0.02 0.93 0.88-0.99 Depression 15.23 < 0.001 5.88 2.42-14.31 diagnosis Abbreviations: MMSE = Mini-Mental State Examination; and CVFT = category verbal fluency test.
A previous local study (13) found that the mean [+ or -] standard deviation (SD) CVFT score of the subjects was 29.93 [+ or -] 9.89, and 37.73 [+ or -] 9.09 for the healthy controls.
Independent variables, including cognitive test scores (MMSE, ADAS-Cog, delayed recall test, CVFT, VADS test, TMT), functional assessment score (DAD scale), mood scores (HRSD, NPI-apathy), cardiovascular risk burden, and duration of current depressive episode were examined to look for predictors of remission at 12 and 24 weeks.
The depression group showed significant cognitive impairment compared to the NC group in all cognitive tests including global cognitive function, delayed recall memory, working memory, and CVFT
. The depression group had more prominent impairment in episodic memory than for other cognitive domains, as reflected in the Z scores (Fig 1).
Age, CMMSE score, ADAS-Cog total score, 10-minute delayed recall and CVFT scores yielded significant correlations with all MacCAT-T summary scores.
The analysis, as shown in Table 4, revealed that the Understanding score was significantly predicted by the ADAS-Cog total score ([beta] = -0.4, p = 0.01) and the CVFT score ([beta] = 0.3, p = 0.04), and that the relationship accounted for about 45% of the variance of the Understanding score.